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Apocynin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
2021
Bratislava Medical Journal
The aim was to investigate the improvement properties of apocynin and its potential mechanism on diabetes-associated cognitive decline. In this study, the model of diabetic rat was established by STZ (50 mg/kg) and treated with apocynin (16 mg/kg/d for 12 weeks). The cognitive ability was evaluated by Morris water maze test. The indicators of oxidative stress (SOD and MDA) were analyzed by spectrophotometer. The inflammatory cytokines were measured by real time-PCR and ELISA. The protein
doi:10.4149/bll_2021_010
pmid:33393325
fatcat:owpyp7yrxrg2nlncyac7hwnjcm