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Activation of Rac1 and RhoA Preserve Corneal Endothelial Barrier Function
Investigative Ophthalmology and Visual Science
PURPOSE. The corneal endothelium is responsible for the correct hydration of the corneal stroma. Corneal endothelial cells have a low proliferative capacity, so preserving their barrier function under suboptimal conditions that cause osmotic imbalance, such as those arising from corneal pathologies, age, cryopreservation, and transplantation, is essential for maintaining corneal transparency. We have investigated the signaling induced by hyperosmotic shock that reversibly disrupts cornealdoi:10.1167/iovs.16-20031 pmid:27849309 fatcat:2aglh4ywerdedmmq5hnwb5ivs4