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The -Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes
We examined the association between ␣-adducin 1 (ADD1) gene polymorphism (Gly460Trp) with macrovascular complications and mortality in type 2 diabetes in a Caucasian population aged >55 years. The study was part of the Rotterdam Study, a prospective population-based cohort study. ADD1 polymorphism was determined in 6,471 participants, including 599 patients with type 2 diabetes at baseline. The prevalence of hypertension in type 2 diabetic patients was 2.57 times higher in ADD1 TT carriersdoi:10.2337/db06-0302 pmid:17003363 fatcat:3pjazjcikjhnxl4i5ygudmrntu