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THE METABOLIC DISPOSITION OF THYMOXAMINE HYDROCHLORIDE
Journal of The Showa Medical Association
The metabolic disposition of thymoxamine hydrochloride (thymoxamine), in paticular its pharmacokinetics and bioavailability, was investigated in rats, beagle dogs and rabbits. After oral or intravenous administration of thymoxamine to animal species, free and conjugated forms of deacetyl-thymoxamine (DAM) and deacetyl-demethyl-thymoxamine(Met-X) were detected in plasma and tissues, without unchanged thymoxamine. From examination of pharmacokinetic parameters, it is suggested that thymoxaminedoi:10.14930/jsma1939.45.739 fatcat:6mmshyxqlfcbbk5vqicdzpub7e