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+)-Neopeltolide was isolated from a deep-water sponge of the family neopeltidae. Due to its attractive novel structure and highly potent anticancer activity, more than twenty total and formal syntheses have been reported in last decade. Herein, the synthetic studies toward the total and formal syntheses of neopeltolide are reviewed according to the synthetic strategies toward the macrolactone core.doi:10.6023/cjoc201703017 fatcat:grx5bbcw5zcirmmfbfkthryj5i