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Computational fluid dynamics is a powerful method for scale-up of reactors although it is still challenging to fully embrace hydrodynamics and biological complexities. In this article, an aerobic fermentation of Pichia pastoris cells is modeled in a batch OKTOP®9000 reactor. The 800 m 3 industrial scale reactor is equipped with a radial impeller, designed by Outotec Oy for gas dispersion in the draft tube reactor. Measured N p of the impeller is used in hydrodynamics validation. The resolveddoi:10.1021/acs.iecr.8b02765 pmid:30416255 pmcid:PMC6219852 fatcat:c5vdumcnuzf4zaufzg2j7in23a