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Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
Chemokines are critical mediators of angiogenesis in several physiological and pathological conditions, however a potential role for muscle-derived chemokines in exercise-stimulated angiogenesis in skeletal muscle remains poorly understood. Here, we postulated that the chemokine stromal cell-derived factor-1 (SDF-1α/CXCL12), shown to promote neovascularization in several organs, contributes to angiogenesis in skeletal muscle. We found that CXCL12 is abundantly expressed in capillary-richdoi:10.1152/ajpregu.00155.2019 pmid:31577158 fatcat:syucvvtyfvgi3iprodfvohqrpy