On the development and natural healing of secondary tumours of chorionepithelioma malignum

John H. Teacher
1908 The Journal of Pathology and Bacteriology  
IT has long been believed that malignant tumours occasionally undergo spontaneous healing, and, in spite of its extreme malignancy i n the majority of cases, chorionepithelioma malignum is one of the forms of tumour i n whicb healing has undoubtedly been observed. The reaction which is seen about t h e margins of malignant growths has been regarded as probably of t h e nature of resistance to invasion by t h e tumour, and t h e atrophy of t h e cell processes in the interior of a scirrhus of
more » ... of a scirrhus of the mamma as a process of healing due to cicatricial coutraction of t h e fibrous stroma strangling t h e m ; but it is only since t h e discovery that tumours healed under t h e influence of X-rays that the nature of t h e healing process has been carefully investigated. Finally, t h e successful propagation of carcinomata by Jensen and others has given opportunities of studying t h e healing of tumours in mice a t all stages and under various circumstances. Healing of undoubtedly malignitnt tumours, either spontaneous or as a result of an incomplete operation, has been observed several times. Certain of these cases will be referred to later. With regard to chorionepithelioma, in two cases, those of Fleischmann and Hoermann, it was the primary tumour which healed. I n the latter case, and one of the cases recorded by Langhans, secondary vaginal nodules also healed. Further, in a considerable number of cases a portion of what was supposed to be tumour was left behind at operation without evil result, and other cases have presented the clinical symptoms which are held to indicate the presence of secondary tumours in the lungs, yet after removal of the primary growth these disappeared and complete recovery took place. In the case published by Dr. Kelly and myself in 1898, although the disease was of a very malignant type and ended fatally, we observed nodules in the right Fallopian tube, and in blood vessels about the uterus and bladder, which appeared to be extinct. The nature of these nodules and the fact that Demonstrated to the Pathological Society of Great Vide abstract in Joum. of Path. and [
doi:10.1002/path.1700120304 fatcat:y7t22afjl5fvbehxtcfwj5b7mi