Advances in the research on application of KL-6 in the diagnosis and treatment of interstitial lung disease

Ran-ran WANG, Jian ZHU, Jiang-lin ZHANG
2017 Medical Journal of Chinese People's Liberation Army  
Interstitial lung disease represents a group of diffuse pulmonary diseases that mainly affects pulmonary mesenchyme and alveolar spaces, resulting in loss of alveolar-capillary functions. It is also a common complication or an important factor that influences the prognosis of rheumatoid arthritis, dermatomyositis, systemic sclerosis. Searching for the biomarkers for the early diagnosis of the disease and/or indicative of the activity of the condition has been a subject of active investigations.
more » ... ive investigations. KL-6, expressed on type II pneumocytes, is seen as the most promising biomarker for the diagnosis of the disease. This review summarizes the recent researches about the use of KL-6 in the diagnosis and treatment of interstitial lung disease. DOI: 10.11855/j.issn.0577-7402.2017.04.15
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