The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity

Biyin Cao, Jie Li, Jingyu Zhu, Mingyun Shen, Kunkun Han, Zubin Zhang, Yang Yu, Yali Wang, Depei Wu, Suning Chen, Aining Sun, Xiaowen Tang (+4 others)
2013 Journal of Biological Chemistry  
Clioquinol is a potent chelator of divalent metal ions including zinc. Results: Clioquinol fits the zinc-centered active pocket of HDACs and inhibits HDAC activity, which results in cell cycle arrest and cancer cell apoptosis. Conclusion: Clioquinol inhibits HDAC activity and induces blood cancer cell death. Significance: This is the first report to demonstrate that clioquinol inhibits HDAC activity.
doi:10.1074/jbc.m113.472563 pmid:24114842 pmcid:PMC3837159 fatcat:vktyayk5xzbkvk3sbqatu6worq