Amavata is the most challenging disease for the medical science, as it causes severe intolerable pain and severe deformities making the patient disable and bedridden. As it is the disease of Rasavaha Srotas and having several features similar to Rheumatoid Arthritis, Amavata can be correlated with Rheumatoid Arthritis (RA). Amavata is the outcome of Agnidushti, Amotpatti and Sandhivikrutti, with the passage of the time most of the dietary habits, changing lifestyle and environment have been

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... ributing to the disease, the risk factor include age, gender, genetics and environmental exposures. Hence Amavata have became a challenge to the human race. Management of the disease is merely insufficient in other system of medicine, in such condition disease which continues to pose challenge to the physician as well as for patients due to severe morbidity and crippling nature. So patients are continuously looking for the treatment from Ayurved to overcome this challenge. It also shows extra articular features like bodyache, stiffness etc. many research have been carried out to solve this clinical enigma.The therapy which normalizes Agni metabolizes Ama and regulates Vata and maintain healthy Sandhi and Sandhistha Shelshma will be the supreme one for this disease. The formulations of Amavatavidhvansa Rasa and Simhanaada Guggula is indicated, especially in treating the Amavata.