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Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond
2021
Annual Review of Biochemistry
In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's core was the modular assembly of regulators, operators, and structural genes. To illustrate the composability of these elements, Jacob and Monod linked phenotypic diversity to the architectures of regulatory circuits. In this review, we examine how the circuit blueprints imagined by Jacob and Monod laid the foundation for the first synthetic gene networks that launched the field of synthetic biology in 2000.
doi:10.1146/annurev-biochem-013118-111914
pmid:33784178
fatcat:63g3sejl7rao3i3wswbnz4pm3q