Development of Scanning Probe Electrospray Ionization Mass Spectrometry and Label Free Mass Imaging of Biological Tissue Section
走査型プローブエレクトロスプレーイオン化質量分析法の開発と生体組織のラベルフリー質量イメージングへの応用

Yoichi OTSUKA
2016 Hyomen Kagaku  
Understanding the spatial distribution of chemical components inside materials is essential to make advances in science and technology. Scanning probe electrospray ionization mass spectrometry (SPESI-MS) is an analytical technique to realize the ambient sampling and ionization. The fusion of the electrospray ionization technique in mass spectrometry and the technique used in scanning probe microscopy has given a birth to a new analytical method. The demonstration of a label-free mass imaging of
more » ... biological tissue sections showed the possibility of bio-marker detection and or discovery by SPESI-MS. KEYWORDS : ambient sampling and ionization, scanning probe, chemical imaging, label-free imaging, biomarker 37 7 2016 316
doi:10.1380/jsssj.37.315 fatcat:rsq2c5rn3jeffdui26wnozbtzi