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Is there an Association between the H1N1 Influenza Pandemic Vaccination and the Manifestation of Narcolepsy?
Journal of Vaccines & Vaccination
After the mass-vaccination campaign during the influenza A (H1N1) 2009 pandemic, a significant increase in narcolepsy incidence was observed initially in Scandinavia, later in other European countries and recently also in Canada. Narcolepsy is a sleep disease caused by the loss of hypocretin-producing cells in the hypothalamus. Almost all narcolepsy patients carry the HLA-DQB1 * 0602 allele, giving a link to an autoimmune-mediated process. Most of the observed narcolepsy cases were correlateddoi:10.4172/2157-7560.1000280 fatcat:lrhk4353pzcrnan4wq747subau