Aspectos regio- e estereoquímicos da adição de Michael assimétrica via iminas quirais com centros estereogênicos pré-existentes

Rossana A. Schenato, Éverton M. dos Santos, Beatriz S. M. Tenius, Eduardo R. de Oliveira
2003 Química Nova  
Recebido em 20/8/02; aceito em 21/2/03 REGIO-AND STEREOCHEMICAL ASPECTS OF THE ASYMMETRIC MICHAEL ADDITION USING CHIRAL IMINES BEARING A RESIDENT STEREOGENIC CENTER. The asymmetric Michael addition reactions using chiral imines, under neutral conditions (deracemizing alkylation process), constitute one of the main methods for the stereocontrolled elaboration of quaternary carbon centers. This protocol is based on the conjugate addition of secondary chiral enamines to electron-deficient alkenes.
more » ... -deficient alkenes. The focus of this report deals with the discussion of regio-and stereochemical aspects of the deracemizing alkylation process concerning enamines bearing a resident chiral center.
doi:10.1590/s0100-40422003000500016 fatcat:65wjjewlobcunlozcncrko3dem