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Interrelationships of flow, intravascular pressure, and tissue perfusion in the measurement of capillary permeability to sodium in isolated dog lung lobes
From venous tracer-dilution curves, after 57 pulse injections of "NaCl and [ 13I I]albumin (RISA) into the arterial inflow of nine isolated canine lung lobes perfused with blood (hematocrit = 0.24-0.44) under zone III conditions, we calculated area-weighted fractional extractions (E 3 ) and capillary permeability (P)-surface area (S) products (PS) for 24 Na at plasma flows (F p ) ranging from 4.1 to 40.1 ml»min" 1 «g" 1 dry weight. In six of the lobes, 35 separate injections of RISA and [ l25doi:10.1161/01.res.46.5.669 pmid:7363416 fatcat:c62nm5x225delinqfxouc5uevi