Differential expression of SERTAD4 antisense RNA 1 in human epithelial ovarian cancer [post]

Shahan Mamoor
2021 unpublished
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified both coding and non-coding SERTAD4 transcripts as among those whose
more » ... ession was most different in epithelial ovarian cancer as compared to the normal fallopian tube or ovary. Expression of a SERTAD4 antisense transcript, SERTAD4-AS1, was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. SERTAD4-AS1 expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of SERTAD4-AS1 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. SERTAD4 coding and non-coding RNAs may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.
doi:10.31219/osf.io/7vngq fatcat:golpbnqbfjg5lm425x35xgl2hm