The High Prevalence of Testicular Adrenal Rest Tumors in Adult Men With Congenital Adrenal Hyperplasia Is Correlated With ACTH Levels

Rossella Mazzilli, Antonio Stigliano, Michele Delfino, Soraya Olana, Virginia Zamponi, Cristina Iorio, Giuseppe Defeudis, Danilo Cimadomo, Vincenzo Toscano, Fernando Mazzilli
2019 Frontiers in Endocrinology  
Conclusions: T-ARTs were detected in 56% of patients with CAH and were associated with impaired semen parameters. However, these lesions are potentially reversible, as demonstrated by the disappearance/reduction after adjustment of cortisone therapy and by the reduction in plasma ACTH level. Our study supports the importance of periodic US evaluation and maintenance of plasma ACTH levels within the normal range in men with CAH.
doi:10.3389/fendo.2019.00335 fatcat:7vnf3obpvvcp5ngeldfixee72i