HBV genotype-dependent association of HLA Variants with the Serodecline of HBsAg in Chronic Hepatitis B Patients: a 14-year Follow-up Study [post]

Yu-Ju Chu, Hwai-I Yang, Hui-Han Hu, Jessica Liu, Yu-Ling Lin, Chia-Ling Chang, Wen-Sheng Luo, Chin-Lan Jen, Chien-Jen Chen
2022 unpublished
Background and Aims Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the functional cure of chronic hepatitis B (CHB). The relationship between human leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal HBsAg serodecline remains to be explored. Methods A total of 2498 HBeAg-seronegative CHB patients of the community-based REVEAL-HBV cohort were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay. Cox proportional hazard regression and
more » ... eneralized linear mixed models were used to analyze the association of HLA genetic variants with the rate of HBsAg seroclearance and longitudinal HBsAg serodecline. Results Rs1710 G allele was differentially associated with the HBsAg seroclearance in genotype B [aRR (95% CI)=0.74 (0.56-0.98)] and genotype C [aRR (95%CI)=1.43 (1.08-1.88)] infection. Rs2770 G allele was associated with HBsAg seroclearance only in genotype B infection [aRR (95% CI)=0.69 (0.52-0.91)]. The alleles associated with HBsAg seroclearance were significant predictors for the serodecline of HBsAg levels in an HBV genotype-dependent manner (genotype B infection: rs1710, p=0.013; rs2770, p=0.0081; genotype C infection: rs1710, P=0.0452). Conclusions Our results suggest both spontaneous HBsAg seroclearance and serodecline are modified by the interaction between HLA variants and HBV genotype.
doi:10.21203/rs.3.rs-2121733/v1 fatcat:t6jce3izd5d5bhwjn464hw2x3u