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HBV genotype-dependent association of HLA Variants with the Serodecline of HBsAg in Chronic Hepatitis B Patients: a 14-year Follow-up Study
Background and Aims Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the functional cure of chronic hepatitis B (CHB). The relationship between human leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal HBsAg serodecline remains to be explored. Methods A total of 2498 HBeAg-seronegative CHB patients of the community-based REVEAL-HBV cohort were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay. Cox proportional hazard regression anddoi:10.21203/rs.3.rs-2121733/v1 fatcat:t6jce3izd5d5bhwjn464hw2x3u