Insulin resistance and thyroid hypofunction in obese women – A cross sectional study

Faraz Farishta, Shaista Farishta
2015 Integrative Obesity and Diabetes  
We evaluated the relationship between thyroid hypofunction and insulin resistance among obese female patients visiting to endocrinology outpatient clinics (OPD) done at Sparsh Endocrinology & Diabetic Center. In this cross-sectional study, a total of fifty female subjects with age group of 30-60 years, whose body mass index was above 30 kg/m2 were studied for 16 months between July 2013 to November 2014 who were attending our endocrinology OPD were studied. Subjects with known disease or
more » ... n disease or disorder of endocrine systems or who were receiving medications like, thyroid hormones preparations, Lithium, Amiodarone or corticosteroids were excluded. Blood samples were assed for T3, T4, TSH, FBS, Fasting Insulin and HOMA IR was calculated. A total of fifty subjects participated in the study. The mean age of the patients was 31.4 ± 7.32 years. Among these subjects TSH analysis revealed that 26% were having subclinical hypothyroidism (SCH). We found that 46% of these SCH subjects are having insulin resistance while 24% of patients with normal thyroid function are having insulin resistance as estimated by HOMA IR. P-value=0.6 and the odds ratio is 0.667, with a 95% confidence interval extending from 0.19 to 2.09. The observed difference in insulin resistance was not statistically between the subjects with SCH and normal obese subjects. In our study we observed that insulin resistance co exists with thyroid-hypo function in 46% of obese subjects. Caution has to be executed in interpretation of results as our sample is small. Arishta F (2015) Insulin resistance and thyroid hypofunction in obese women -A cross sectional study
doi:10.15761/iod.1000123 fatcat:vqihtwun25dgvif67jsk6eaemm