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Synthesis, characterisation and biological activity of novel spiroheterocycles from semicarbazones
2012
Scholars Research Library Der Pharma Chemica
unpublished
A facile synthesis and characterization of novel spiropyrrolidines is reported. Reaction of isatin and L-proline with semicarbazone gave the corresponding spiropyrrolidines. Intermolecular 1, 3-dipolarcycloaddition reaction of azomethine ylides, generated through decarboxylation route, with various semicarbazone as dipolarphiles has been investigated. A new class of functionalized spiroheterocycles with pyrrolidine moiety has been synthesized. The formation of spiro heterocycles was confirmed
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