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Motivation: With rapidly increasing volumes of biological sequence data the functional analysis of new sequences in terms of similarities to known protein families challenges classical bioinformatics. Results: The ultrafast protein classification (UProC) toolbox implements a novel algorithm ('Mosaic Matching') for large-scale sequence analysis. UProC is by three orders of magnitude faster than profile-based methods and in a metagenome simulation study achieved up to 80% higher sensitivity ondoi:10.1093/bioinformatics/btu843 pmid:25540185 pmcid:PMC4410661 fatcat:ykeqts7pcnduvjgzuhdhvlsy4q