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Thirty-five strains of arbovirus were tested for replication in mouse embryo cell cultures; twenty-six of these multiplied and were cytopathogenic. Dengue I and dengue 2 may have multiplied without cytopathogenicity. Twenty-three of the viruses were also tested for the production of complement-fixing antigen; twentytwo were positive. Similar end-points were attained using standard inoculum doses in both tubes and mice for parallel titrations of selected viruses. A major advantage of mousedoi:10.1099/0022-1317-10-2-173 pmid:5553710 fatcat:lqgkc2bh35f3zgmixjl52kur34