Measurement of anisotropic mechanical properties in porcine brain white matter ex vivo using magnetic resonance elastography

J.L. Schmidt, D.J. Tweten, A.A. Badachhape, A.J. Reiter, R.J. Okamoto, J.R. Garbow, P.V. Bayly
2018 Journal of The Mechanical Behavior of Biomedical Materials  
The mechanical properties of brain tissue, particularly those of white matter (WM), need to be characterized accurately for use in finite element (FE) models of brain biomechanics and traumatic brain injury (TBI). Magnetic resonance elastography (MRE) is a powerful tool for non-invasive estimation of the mechanical properties of soft tissues. While several studies involving direct mechanical tests of brain tissue have shown mechanical anisotropy, most MRE studies of brain tissue assume an
more » ... pic model. In this study, an incompressible transversely isotropic (TI) material model parameterized by minimum shear modulus (μ 2 ), shear anisotropy parameter (ϕ), and tensile anisotropy parameter (ζ) is applied to analyze MRE measurements of ex vivo porcine Abstract Keywords MR elastography; shear waves; anisotropy; transversely isotropic material; white matter brain tissue Schmidt et al.
doi:10.1016/j.jmbbm.2017.11.045 pmid:29253729 pmcid:PMC5807163 fatcat:cqr66nfcozcr5kxqbezp2eboau