AUTOMATIC MULTISYRINGE FLOW INJECTION SYSTEM FOR THE SPECTROPHOTOMETRIC DETERMINATION OF TINIDAZOLE IN PHARMACEUTICAL PREPARATIONS

J.L GUZMÁN-MAR, L HINOJOZA-REYES, A HERNANDEZ-RAMÍREZ, J.M PERALTA-HERNANDEZ, V.J LÓPEZ-CHUKEN, P.L LÓPEZ-DE-ALBA, V CERDA-MARTÍN
2010 Journal of the Chilean Chemical Society (Print)  
A multisyringe flow injection analysis (MSFIA) method for the determination of tinidazole (TNZ) in pharmaceutical preparations was developed. TNZ concentrations were determined by spectrophotometric detection at 374 nm wavelength using a light emitting diode (LED). The MSFIA parameters were optimized. Under the optimized experimental conditions, a linear dynamic range from 2 to 56 mg L -1 TNZ, a 3σ detection limit of 0.3 mg L -1 , and a 10σ quantification limit of 1.2 mg L -1 were obtained. The
more » ... were obtained. The relative standard deviation (%R.S.D.) at 2, 28 and 56 mg L -1 was 2.3, 1.4 and 0.9%, respectively (n = 10). A sample throughput of 76 determinations/h was achieved.
doi:10.4067/s0717-97072010000200015 fatcat:4dco2hqpljecpfvyc32j543u2y