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2D electrophoresis is a well known method for protein separation which is extremely useful in the field of proteomics. Each spot in the image represents a protein accumulation and the goal is to perform a differential analysis between pairs of images to study changes in protein content. It is thus necessary to register two images by finding spot correspondences. Although it may seem a simple task, generally, the manual processing of this kind of images is very cumbersome. The complete task ofdoi:10.1109/sibgrapi.2008.14 dblp:conf/sibgrapi/NomaPJ08 fatcat:yj5easkeb5gw3javhrftd3fmhy