Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang (+2 others)
2017 Molecules  
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3 -O-α-L-arabinopyranoside (1), (9R)-moracin P 9-O-β-D-glucopyranoside (2), (9R)-moracin P 3 -O-β-D-glucopyranoside (3), and (9R)-moracin O 10-O-β-D-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three
more » ... s. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain. The molecular docking with metabotropic glutamate receptor 1 (mGluR 1 ) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR 1 pathway.
doi:10.3390/molecules22020236 pmid:28208727 fatcat:i4txx2zdbjbcnkzsoi4l24rixy