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Design and antiviral properties of influenza virus neuraminidase inhibitors
1995
Pure and Applied Chemistry
During the infection cycle of influenza virus, progeny virions bud from the plasma membrane of infected cells. At that point they are potentially immobilised because of interactions between the viral haemagglutinin and sialic acid which is found in glycoconjugates on the cell surface and on glycoproteins of the virus itself Neuraminidase inhibitors might therefore be expected to have an antiviral action by slowing release and subsequently reducing the viral burden in infected hosts. The
doi:10.1351/pac199567101683
fatcat:73mre2ezhnbvtmxj4enljcc5gy