Letters diurnal variability is abnormal. As the authors state, in order to assign to these findings their true importance, one needs evidence that this abnormal BP variability is harmful, and particularly one needs evidence that pharmacological targeting of BP during sleep to confer a 'normal' variability where one did not exist before, will be beneficial in terms of biologically significant cardiovascular endpoints. Regrettably, such very large, lengthy, multicentre trials in renal secondary

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... pertension are very unlikely indeed to be forthcoming.