Functional multineuron calcium imaging for systems pharmacology

Naoya Takahashi, Yuji Takahara, Daisuke Ishikawa, Norio Matsuki, Yuji Ikegaya
2010 Analytical and Bioanalytical Chemistry  
Functional multineuron calcium imaging (fMCI) is a large-scale technique used to access brain function on a single-neuron scale. It detects the activity of individual neurons by imaging action potential-evoked transient calcium influxes into their cell bodies. fMCI has recently been used as a high-throughput research tool to examine how neuronal activity is altered in animal models of brain diseases, for example stroke, Alzheimer's disease, and epilepsy, and to estimate how pharmacological
more » ... s act on normal and abnormal states of neuronal networks. It offers unique opportunities to discover the mechanisms underlying neurological disorders and new therapeutic targets.
doi:10.1007/s00216-010-3740-6 pmid:20437032 fatcat:cipi4cgstrgibjzyed4fa3lgaq