Original Article Factors associated with sinus rhythm maintenance after surgical ablation in concomitant atrial fibrillation patients: a systematic review and meta-analysis

Kang Gao, Li-Wei Chen, Yi-Guang Sun
2016 Int J Clin Exp Med   unpublished
s: Background: The efficacy of surgical ablation in patients with atrial fibrillation (AF) remains controversial. It is currently rather difficult to identify those AF patients who may benefit the most from this surgical strategy. The aim of this study was to perform a systematic review of risk factors for sinus rhythm maintenance after surgical ablation in concomitant AF patients. Methods: Trials of multiple risk factor interventions for the sinus rhythm maintenance of patients with AF after
more » ... rgical ablation were searched in MEDLINE, PubMed, Cochrane Library, and EMBASE databases, from their inception to Dec 2012. According to the heterogeneity of the studies, two different models, namely, Fixed Effect Model and Random Effect Model were applied to analyze the results. Results: Screened according to inclusion and exclusion standards, eleven trials with a total of 1099 subjects were eventually included in the meta-analysis. Five parameters were associated with recurrence of AF: (1) Duration of AF (Mean Difference: 2.05; 95% confidence interval: 0.29 to 3.80; P=0.0005); (2) Left atrial diameter (Mean Difference: 6.24; 95% confidence interval: 4.85 to 7.62; P<0.0001); (3) Tricuspid valve disease (odds ratio: 2.95; 95% confidence interval: 1.66 to 5.23; P=0.0002); No significant changes were noticed in other parameters. Conclusions: AF patients with long duration of AF, large left atrial diameter, along with tricuspid valve diseases, are more likely to take recurrence of AF after surgical ablation in concomitant AF patients.