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Polymerization of misfolded Z alpha-1antitrypin protein lowers CX3CR1 expression in human PBMCs
2021
eLife
The CX3CR1 (chemokine (C-X3-C motif) receptor 1) expression levels on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its specific ligand CX3CL1 (fractalkine) expression remain largely unknown. Recent studies provide evidence that host's misfolded proteins occurring in the forms of polymers or amyloid fibrils can regulate CX3CR1 expression. Herein, a novel example
doi:10.7554/elife.64881
fatcat:3ak4w5cslfha5fujjix6gpbwte