Identification Of Active Sites And Calculation Of Structural Parameters For The Her2 Target Receptor

K. Ramanathan
2017 Zenodo  
The aim of this work is to identify the active sites and the calculations of structural parameters for the HER2 target receptor. The active site is the key factor where the ligand molecule can able to bind with the receptor. The stability of the interactions between the target receptor and the ligand are maintained by the structural parameters. HER2 receptor is associated with the breast cancer and it is the ideal target for the therapeutic activity. If the structural alterations occur in the
more » ... ions occur in the HER2 it is failed to over expression and it leads to various types of tumours. The structural model could be constructive to recognize the hydrogen bonding and hydrophobic interactions with the ligand in the active sites of the receptor.
doi:10.5281/zenodo.262966 fatcat:te4aauzkzjfk5ghyea7u2wevbi