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TMATCH: A New Algorithm for Protein Alignments using amino-acid hydrophobicities
[article]
2019
bioRxiv
pre-print
The identification of proteins of similar structure using sequence alignment is an important problem in bioinformatics. We describe TMATCH, a basic dynamic programming alignment algorithm which can rapidly identify proteins of similar structure from a database. TMATCH was developed to utilize an optimal hydrophobicity metric for alignments traceable to fundamental properties of amino-acids. Standard alignment algorithms use affine gap penalties as contrasted with the TMATCH algorithm adaptation
doi:10.1101/2019.12.16.878744
fatcat:nw3ryl43drgejfn3cxezj5eati