The objective of this study was to investigate the efficacy of using ionic liquid-based microwave-assisted (IL-MAE) approach for extraction of oxyresveratrol from Morus alba roots and to compare the result with conventional extraction. The roots were extracted with nine IL, 1-butyl-3-methylimidazolium chloride (BmimCl), 1-butyl-3-methylimidazolium bromide (BmimBr), or 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF 4 ) at concentration 1.5, 1.67, and 2 M for each IL, in a microwave at

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... r 30% for 10 minutes respectively. The extracts were filtrated and diluted with 30 ml of deionized water. Then, fractionated with ethyl acetate and salting out by addition of Na 2 CO 3 or KH 2 PO 4 . The fractions were analyzed for oxyresveratrol contents with TLC-densitometer and HPLC. Then the result was compared with conventional methods. IL-MAE approach showed improvement extraction efficiency compared to the conventional ethanol and methanol macerations. The optimized solvent condition for extraction of oxyresveratrol from Morus alba root was 1.5 M BmimCl with 0.01 M KH 2 PO 4 salt. Oxyresveratrol was separated by ethyl acetate fractionation, and the yield calculated was 3.53% from raw material. The study showed that IL-MAE was an efficient method for the extraction of oxyresveratrol from Morus alba roots. How to cite this article: Fadhila M, Mun'im A, Jufri M. Ionic Liquid-based Microwave-Assisted Extraction (Il-MAE) of Oxyresveratrol from Morus alba Roots. J App Pharm Sci, 2018; 8(06): 008-013.