Transcatheter Aortic Valve Replacement in Female Patients—Present Scenario

Osnat Itzhaki Ben Zadok, Katia Orvin, Ran Kornowski
2017 Indian Journal of Cardiovascular Disease in Women WINCARS  
AbstractSince the publication of the pivotal PARTNER study, the transcatheter aortic valve replacement (TAVR) procedure has been established as a noninferior alternative to the traditional aortic valve replacement surgery in severe aortic stenosis (AS) patients with high-surgical risk. Approximately 50% of patients undergoing TAVR are females, and cumulative findings from various worldwide cohorts have shown sex-related differences in short- and long-term morbidity and mortality. Notably, most
more » ... ity. Notably, most data indicate improved long-term mortality in female patients. These differences are partly the results of distinct anatomical and physiologic characteristics in female patients, compared with male patients. Nevertheless, recent data from intermediate-surgical risk cohorts have demonstrated that sex-related mortality differences are less apparent. Here, we review the latest literature on the influence of patient's sex on TAVR morbidity and mortality and discuss possible explanations for the outcomes presented.
doi:10.1055/s-0037-1607211 fatcat:sdfw6ko2l5ebratojntwim3gle