On the dysentery toxin

H. Lüdke
1905 The Journal of Pathology and Bacteriology  
IN connection with the protection of the organism against microorganisms and their toxins, numerous experiments have now been made. These experiments have aimed, on the one hand, at perfecting the efkacious components of the protoplasm of the bacilli, and, on the other, a t producing extremely virulent extracellular toxins. A.n attempt has been made, in order to secure active immunity, to cultivate most virulent cultures of various bacilli. As an example, I may cite the effects of active
more » ... ts of active immunisation against the typhoid bacillus made during the South African War by Wright, who, although he lays great stress upon the value of virulent cultures, does not omit to mention the disagreeable secondary effects-such as headache, nausea, violent pain in the joints, rise of temperature, infiltrations a t the seat of injection-after the in,jection of small doses of living cultures. These troublesome secondary effects remained almost unaltered when, following the recommendation of Wassermann, Kitasato, and Brieger, macerated cultures were used instead of living organisms, though one single injection of this macerated culture was sufficient for the production of bacteriolytic serum; and the proceeding offered, in its practical application, an important safeguard for the physician. Not long ago it was recognised that virulence i s not the sole factor to be considered in the production of immunity; it was soon found that the faculiy of producing immunity has its existence not merely in the micro-organisms, but that, as a matter of fact, specifi cells are the producers of specifi amboceptors. The nature of this specific process of cell secretion is still unknown to us. However, after proving the existence of products of the cell action in the serum, a new way was opened up for arriving a t new conceptions and grasping laws which afford a better explanation than has hitherto been obtainable of the bio-chemical process of immunity, the principal characteristic of which -it must once more be pointed out-consists in the specific action of particular cells, as in typhoid fever for instance, in the action of the blood-producing organs. We therefore had a new law when, as regards typhoid fever, Wassermann proved that virulence is not the determining factor in the production of immunity, and that a way more likely to lead to successful results was indicated by the quantitative
doi:10.1002/path.1700100402 fatcat:zn6vo3ees5hl3mlbtgvgghcxoe