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In genetic association studies outcome dependent sampling is often used in order to increase power. When analyzing the data, correction for the ascertainment scheme generally has to be made to avoid bias. Such correction is however not available in standard statistical methods when the data structure and/or the ascertainment scheme is complex. In this report three simulation based approaches that can be used for correction of known ascertainment schemes are described. These methods providedoi:10.2307/2669561 fatcat:xfca3tq43rgf5bkicdkdcoym4q