Our study was conceptualised to evaluate and compare the effects of two different doses of dexmedetomidine infusion after single loading dose not only for attenuation of hemodynamic response to laryngoscopy and intubation but also to evaluate the efficacy to reduce post-operative analgesic requirement and its effect on sedation score post-operatively. Methods: This prospective randomized study was conducted in the postgraduate Department of Anaesthesiology and Intensive care, Government Medical

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... College, Jammu after getting approval from Institutional ethical committee. Around 120 patients of either sex ranging in age from 18 to 60 years, belonging to ASA physical status grade 1 and 2, scheduled for elective laparoscopic cholecystectomy under general anaesthesia with endotracheal intubation were enrolled for the study. Results: Dexmedetomidine infusion of 0.5 m g/kg /h after loading dose of 1 mg/kg resulted in stable, steady and smooth reduction in heart rate, and arterial blood pressure with no episode of severe hypotension or other adverse event. The total analgesic requirement in 24 hours in group D1 was 123.83±6.08 mg. The total analgesic requirement in 24 hours in group D2 was 83.72±4.28 mg. The difference between the two groups was statistically significant. Conclusion: Dexmedetomidine infusion of 0.5 mg/kg /h after loading dose of 1 mg/kg successfully maintained hemodynamic stability both intraoperatively and postoperatively. This dose increased the pain free period postoperatively, thus reducing the total analgesic requirement. Dexmedetomidine can, therefore, be considered an anaesthetic adjuvant in laparoscopic cholecystectomy and infusion dose of 0.5mg/kg/h is better than 0.2 mg/kg/ h after loading dose of 1 mg/kg. Keywords: Dexmedetomidine; hemodynamic response; tracheal intubation.