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Cryo-EM structure of human Wntless in complex with Wnt3a
Wntless (WLS), an evolutionarily conserved multi-pass transmembrane protein, is essential for secretion of Wnt proteins. Wnt-triggered signaling pathways control many crucial life events, whereas aberrant Wnt signaling is tightly associated with many human diseases including cancers. Here, we report the cryo-EM structure of human WLS in complex with Wnt3a, the most widely studied Wnt, at 3.8 Å resolution. The transmembrane domain of WLS bears a GPCR fold, with a conserved core cavity anddoi:10.21203/rs.3.rs-144481/v1 fatcat:ivqbj3acrzftbmaoqviktce6by