Tramadol is a synthetic centrally acting analgesic used for treatment of moderate to severe acute or chronic pain. In tramadol overdose, seizures and hypotension are present. Intravenous lipid emulsion (ILE) is considered as effective treatment for local anesthetic-induced cardiovascular collapse, and treating overdoses of parasiticides, and herbicides. Aim: the aim of this work was to evaluate the role of ILE in acute tramadol toxicity as regarding hemodynamic instability and seizures in adult

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... male albino rats. Materials and Methods: Eighty adult male albino rats were divided into five groups: Group I (control group). Group II normal saline, Group III lipid emulsion group (subdivided into ILE10, ILE19 subgroups). Group IV (tramadol treated group). Group V: (tramadol and normal saline treated group). Group VI: divided into tramadol+ILE10 and tramadol+ILE19 subgroups. Measurement of blood pressure, monitoring of heart rate and observation for occurrence of seizures were recorded. Results: Different doses of ILE significantly normalized DBP and HR. After infusion of ILE 20%, MAP was significantly stabilized. The ILE10 group had higher MAP at 6 hours, whereas such effect was seen only in ILE19 after 24 hours. There was a decrease in seizures occurrence in ILE treated groups. Serum CPK levels were significantly raised after tramadol toxicity and reduced to normal ranges when ILE was administered in both doses. Tramadol causes Hemodynamic instability and appearance of seizures after once administration (150 mg/kg). ILE could significantly normalize Hemodynamic and seizures of tramadol toxicity. In conclusion: Single administration of tramadol in a dose of 150 mg/kg causes hemodynamic instability and appearance of seizures in adult male albino rats. ILE10 and ILE 19 could significantly normalize hemodynamic and ameliorated the occurrence of tramadol toxicity induced seizures. It is recommended: to do further in vivo studies needed to evaluate role of ILE in chronic tramadol using. Clinicians can consider administration of ILE in resuscitation protocols toxicities causing hemodynamic compromise but the potential risks of administering the quite high doses of ILE are uncertain and needs more researches.