This study aimed to investigate the effi cacy of inspiratory muscle training (IMT) on physical activity in patients with chronic obstructive pulmonary disease (COPD). Methods: Fifty-nine outpatients with stable COPD were enrolled in this study. The participants were randomly assigned to either an IMT group (set intensity at >30% of their maximal inspiratory pressure [PI max ]) or a sham training group (<10% PI max ). Patients of both groups underwent 30 breath IMT sessions twice daily for 3

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... hs. The PI max , 6-minute walk distance (6MWD), daily step counts, and moderate-to-vigorous intensity physical activity time (MVPA) were recorded before and after the 3 months intervention. Results: Fifty participants (23 from the IMT group and 27 from the sham training group) completed the entire assessment. Significant interactions in the PI max , daily step counts, and MVPA were observed. Only patients in the IMT group showed signifi cant improvement in these attributes after the intervention. The 6MWD signifi cantly improved in patients of both groups, and no signifi cant interaction was observed. Conclusion: This study suggests that the IMT improved the PI max and could improve physical activity in patients with stable COPD.