A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
WRN participates in translesion synthesis pathway through interaction with NBS1
2010
Mechanisms of Ageing and Development
Werner syndrome (WS), caused by mutation of the WRN gene, is an autosomal recessive disorder associated with premature aging and predisposition to cancer. WRN belongs to the RecQ DNA helicase family, members of which play a role in maintaining genomic stability. Here, we demonstrate that WRN rapidly forms discrete nuclear foci in an NBS1-dependent manner following DNA damage. NBS1 physically interacts with WRN through its FHA domain, which interaction is important for the phosphorylation of
doi:10.1016/j.mad.2010.06.005
pmid:20600238
pmcid:PMC2911442
fatcat:6lv5qcobufgczekona6atxtkwq