Synthesis of Quinazolinyl Chalcone Derivatives

Heping Yan, Jianguang Shi, Gaozhang Gou, Jucheng Zhang, Dushu Huang, Shijuan Xu, Xuebin Chen, Xuequan Wang, Yong Hong, Wei Liu
2015 Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering   unpublished
4-(4'-quinazolin-ylamino) phenyl-4-(N,N-dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formamidine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde dimethylaminobenzaldehyde. The experimental conditions were optimized. The results showed that: Intermediate 1 was synthesized by
more » ... d by 2-aminobenzonitrile and N, N-dimethylformamide dimethyl acetal and their molar ratio of 1: 2, the optimal reaction temperature is 85 ˚C. Intermediate 2 synthesized optimal temperature of 105 ˚C. Intermediates and target compounds by 1 H NMR, 13 C NMR and mass spectrometry for structural characterization.
doi:10.2991/ic3me-15.2015.61 fatcat:ux2hxfdvkjfrpd7inidefphmwa