Influence of oral MCT or LCT load on glycemia in Wistar and Zucker rats and in guinea pigs

A. BACH, A. WERYHA, H. SCHIRARDIN
1979 Reproduction nutrition development (Print)  
An oral load of medium-chain triglycerides (MCT) (containing fatty acids ranging from C! to C 12 ) in non-fasting Wistar rats induced a decrease in plasma levels of lactate, pyruvate and glucose. These variations were more marked in females than in males of the same age, and were a direct function of the MCT load. Post-MCT hypoglycemia was also observed in previously fasting rats and was definitely determined in guinea pigs, but was not proved in genetically obese Zucker rats. This hypoglycemia
more » ... . This hypoglycemia was preceded by a slight increase in the plasma insulin level. Long-chain triglycerides (LCT) (containing fatty acids over C l2 ) had no effects on the factors studied. It therefore seemed that the large increase in ketone-body levels caused by MCT load induced an increase in insulin secretion, which in turn caused the observed post-MCT hypoglycemia.
doi:10.1051/rnd:19790508 fatcat:334e2owmcvbu3hlakx3sups5vi