Influence of oral MCT or LCT load on glycemia in Wistar and Zucker rats and in guinea pigs

1979 Reproduction nutrition development (Print)  
An oral load of medium-chain triglycerides (MCT) (containing fatty acids ranging from C! to C 12 ) in non-fasting Wistar rats induced a decrease in plasma levels of lactate, pyruvate and glucose. These variations were more marked in females than in males of the same age, and were a direct function of the MCT load. Post-MCT hypoglycemia was also observed in previously fasting rats and was definitely determined in guinea pigs, but was not proved in genetically obese Zucker rats. This hypoglycemia
more » ... . This hypoglycemia was preceded by a slight increase in the plasma insulin level. Long-chain triglycerides (LCT) (containing fatty acids over C l2 ) had no effects on the factors studied. It therefore seemed that the large increase in ketone-body levels caused by MCT load induced an increase in insulin secretion, which in turn caused the observed post-MCT hypoglycemia.
doi:10.1051/rnd:19790508 fatcat:334e2owmcvbu3hlakx3sups5vi