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Infections following CAR-T cells therapy: current state-of-the-art review and recommendations
Acta Haematologica Polonica
The most frequent and severe complications after chimeric antigen receptor T-cells (CAR-T cells) therapy include cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), macrophage activation syndrome/hemophagocytic lymphohistiocytosis (MAS/HLH), tumor lysis syndrome (TLS), followed by B-cell aplasia and hypogammaglobulinemia. With these immunologically related events, cytokine storm and immunosuppression, there is a high risk of sepsis and infectiousdoi:10.2478/ahp-2020-0004 fatcat:sqxyxna7qjhctmqgharqfwu5fe