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Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency
2019
Frontiers in Neurology
Objective: To investigate associations between peripheral innate immune activation and frontotemporal lobar degeneration (FTLD) in progranulin gene (GRN) haploinsufficiency. Methods: In this cross-sectional study, ELISA was used to measure six markers of innate immunity (sCD163, CCL18, LBP, sCD14, IL-18, and CRP) in plasma from 30 GRN mutation carriers (17 asymptomatic, 13 symptomatic) and 29 controls. Voxel based morphometry was used to model associations between marker levels and brain
doi:10.3389/fneur.2019.01004
pmid:31620075
pmcid:PMC6759464
fatcat:joh6zrgepjaxfndjqsbeohfjh4