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Review on Computer-Aided Drug Design (CADD) Technique in Drug Discovery Researches and Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Camphor Sulfonic Acid
Biointerface Research in Applied Chemistry
Combined with various computational and theoretical approaches, computer-aided drug design (CADD) is one of the contemporary approaches to drug discovery. Furthermore, this study briefly assesses the literature on computer-assisted drug design (CADD) techniques used in drug discovery research. An environmentally friendly synthetic route was developed for the convenient Biginelli synthesis of 3,4-dihydropyridine-2-(1H)-ones/thiones when no solvents are involved in the reaction using aromaticdoi:10.33263/briac134.303 fatcat:qvyapobm65dy3fgrt7ciqdevk4