Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein

D. Oliver
2001 Science  
intervene in MD plasticity by mediating the strengthening of active inputs. The existing information allows envisioning two mechanisms by which ERK could exert its actions on activity-dependent synapse strengthening. First, phosphorylated ERK could, at synaptic level, modulate the activity of substrates important for plasticity such as synaptic proteins ( 22 ), ionic channels ( 23 ), or adhesion molecules (24). A second mode of action involves translocation of phosphorylated ERK to the nucleus
more » ... here it activates, directly or through kinases of the p90 ribosomal S6 kinase family, various transcription factors crucial for plasticity (25, 26).
doi:10.1126/science.1060939 pmid:11423665 fatcat:bivd6tchyvhu5mylekym3xz534