OBJECTIVE: The primary objective of the S-CORE registry was to assess the safety and efficacy of the Supralimus-Core ® sirolimus-eluting stent deployment for the treatment of coronary artery disease and event-free survival of patients treated with this coronary stent. METHODS: S-CORE Registry is an observational, single-arm, non-randomized, post-marketing surveillance multicenter registry in which 562 patients undergoing single-or multi-vessel percutaneous coronary intervention were enrolled.

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... e pre-specified primary outcome was the rate of major adverse cardiac events (MACE), defined as the composite of cardiac death, myocardial infarction (MI), target lesion revascularisation (TLR) and target vessel revascularisation (TVR) at 12-month post-procedure. Stent thrombosis (ST) served as the safety endpoint. RESULTS: A total of 640 lesions were treated in 562 enrolled patients (mean age 57.4 ± 10.7 years) with average stent length of 25.0 ± 9.0 mm. Stent delivery was successful in 99% cases. A total of 554 (98.6%) patients have been followed up to 12 months. The incidence of MACE at 30 days and 6 months was 7 (1.2%) and 12 (2.1%) respectively. The composite rate of MACE at a 12-month clinical follow-up was 19 (3.4%), consisting of 12 (2.1%) cardiac deaths, 0 (0%) MI, 6 (1.1%) TLR and 1 (0.2%) TVR. The long-term follow-up of this registry is going on to confirm safety and efficacy profiles. CONCLUSIONS: This multicenter registry demonstrated satisfactory safety and efficacy profiles, as evidenced by low rates of major adverse cardiac events up to 12 months, for the cobalt-chromium biodegradable polymer-based sirolimus-eluting Supralimus-Core ® stent in a "real-world" setting. P. Chandwani et al. Characteristics n = 562 Patients Age (Mean ± SD, yrs) 57.4 ± 10.7 Male, n (%) 479 (85.2%) Diabetes Mellitus, n (%) 140 (24.9%) Hypertension, n (%) 219 (39.0%) Smoker, n (%) 87 (15.5%) Hypercholesterolemia, n (%) 177 (31.5%) Family History of CAD, n (%) 148 (26.3%) PCI Indication Stable Angina, n (%) 89 (15.8%) Unstable Angina, n (%) 219 (39.0%) Previous MI, n (%) 49 (8.7%) Previous PCI, n (%) 67 (11.9%) Previous CABG, n (%) 12 (2.1%) Previous Stroke, n (%) 18 (3.2%) 2 Vessels, n (%) 200 (35.6%) 3 Vessels, n (%) 101 (18.0%) Distribution of lesions Left anterior descending artery, n (%) 368 (57.5%) Right coronary artery, n (%) 131 (20.5%) Left circumflex artery, n (%) 141 (22.0%) ACC/AHA lesion classification A, n (%) 213 (33.3%) B1, n (%) 194 (30.3%) B2, n (%) 175 (27.3%) C, n (%) 58 (9.1%) TIMI flow pre-procedure 0/1, n (%) 240 (37.5%) 2, n (%) 68 (10.6%) 3, n (%) 332 (51.9%) Total no. of stent, n 684 No. of stents per patient, (mean ± SD, mm) 1.22 ± 0.48 No. of stents per lesion, (mean ± SD, mm) 1.07 ± 0.27 Average stent length, (mean ± SD, mm) 25.0 ± 9.0 Average stent diameter, (mean ± SD, mm) 3.0 ± 0.3 Total occlusion, n (%) 143 (22.3%) Long lesions (>20 mm), n (%) 378 (55.3%) Small vessels (2.5 mm), n (%) 79 (11.5%)